Table 2.
Protocols of controlled ovarian stimulation and data of in vitro fertilization and embryo transfer.
| Characteristics | TAI group (N=778) | Control group (N=778) | P values |
|---|---|---|---|
| Protocol of controlled ovarian hyperstimulation | |||
| Ultralong GnRH agonist | 132 (17.0) | 110 (14.1) | 0.286 |
| Long GnRH agonist | 258 (33.2) | 278 (35.7) | |
| Short GnRH agonist | 6 (0.8) | 3 (0.4) | |
| GnRH antagonist | 382 (49.1) | 387 (49.7) | |
| Gonadotropin dose, mean (SD) | 2700 (2025-3450) | 2700 (2025-3525) | 0.664 |
| LH on HCG trigger day, median (IQR), mIU/ml | 1.0 (0.6-2.1) | 1.0 (0.6-2.1) | 0.878 |
| E2 on HCG trigger day, median (IQR), mIU/ml | 6050.0 (4172.0-9216.0) | 5998.0 (4240.0-8682.0) | 0.668 |
| P on HCG trigger day, median (IQR), mIU/ml | 2.0 (1.3-2.7) | 2.0 (1.4-2.7) | 0.990 |
| Endometrial thickness, mean (SD), mm | 11 (10-12) | 11 (10-12) | 0.893 |
| No. of retrieved oocytes per cycle, mean (SD) | 10 (7-13) | 11 (8-14) | 0.091 |
| Fertilization, No (%) | |||
| IVF | 485 (62.3) | 492 (63.2) | 0.714 |
| ICSI | 293 (37.7) | 286 (36.8) | |
| No. of good-quality embryos per cycle, median (IQR) a | 4 (2-6) | 4 (2-6) | 0.988 |
| No. of embryos transferred, No. (%) | |||
| 1 | 122 (15.7) | 110 (14.1) | 0.393 |
| 2 | 656 (84.3) | 668 (85.9) | |
| Timing of embryo transfer, No. (%) | |||
| Day 3 | 720 (92.5) | 711 (91.4) | 0.401 |
| Day 5 | 58 (7.5) | 67 (8.6) |
LH, luteinizing hormone; E2, estradiol; P, progesterone; IQR, interquartile range; SD, standard deviation.
a
Embryos were evaluated on the third day after fertilization. Good-quality embryos were all developed from 2 pronuclei zygotes and met the following criteria:
(1) had more than 5 blastomeres; (2) size difference was less than 20%; and (3) fragmentation was less than 50%.