Table 2.
Thymic epithelial tumor patients with high frequent gene alterations (somatic mutation and copy number alterations) in our cohort and TCGA data.
| Percentage (No.) | Type | Mutation classification | ||
|---|---|---|---|---|
| TP53 | Our data | 14.3% (5) | Type B3, n=1 | Missense variant, n=4 |
| Type C, n=4 | Nonsense variant, n=1 | |||
| TCGA data | 5% (6) | Type A, n=1 | Missense variant, n=3 | |
| Type AB, n=1 | Deletion variant, n=1 | |||
| Type B2, n=1 | CN-del, n=2 | |||
| Type B3, n=1 | ||||
| Type C, n=2 | ||||
| MTOR | Our data | 8.6% (3) | Type A, n=1 | Missense variant, n=3 |
| Type C, n=2 | ||||
| TCGA data | 0.8% (1) | Type C, n=1 | Missense variant, n=1 | |
| BRCA1 | Our data | 8.6% (3) | Type A, n=1 | Missense variant, n=1 |
| Type B3, n=2 | Splice-site, n=1 | |||
| Synonymous variant,n=1 | ||||
| TCGA data | 0.8% (1) | Type C, n=1 | CN-amp, n=1 | |
| NF1 | Our data | 8.6% (3) | Type A, n=1 | Missense variant, n=3 |
| Type C, n=1 | ||||
| TCGA data | 2.4% (3) | Type A, n=2 | Missense variant, n=2 | |
| Type C, n=1 | Nonsense variant, n=1 | |||
| CDKN2A | Our data | 8.6% (3) | Type B3, n=1 | Missense variant, n=1 |
| Type C, n=2 | Nonsense variant, n=2 | |||
| TCGA data | 5% (6) | Type A, n=1 | Deletion variant, n=1 | |
| Type AB, n=1 | CN-del, n=5 | |||
| Type B3, n=2 | ||||
| Type C, n=2 | ||||
| PTCH1 | Our data | 8.6% (3) | Type A, n=1 | Missense variant, n=1 |
| Type B3, n=1 | Nonsense variant, n=2 | |||
| Type C, n=1 | ||||
| TCGA data | 0.8% (1) | Type AB, n=1 | Missense variant, n=1 |
CN-amp, Copy number variation-amplification.
CN-del, Copy number variation-deletion.
Total patient number: Our data, n=35; TCGA data, n=123.