Table 2.
Number of gene connections to insecticides, cannabinoids, and epilepsy across key biological functions related to seizure in the Comparative Toxicogenomics Database.
| Gene | Insecticide Count | CGPD-Tetramer Count |
Epilepsy Gene | ||
|---|---|---|---|---|---|
| Pathway and Gene Name | Symbol | Insecticide | Cannabinoid | ||
| Oxidation-reduction process | |||||
| catalase | CAT | 15 | 29 | 1 | |
| superoxide dismutase 2 | SOD2 | 13 | 67 | 3 | |
| prostaglandin-endoperoxide synthase 2 | PTGS2 | 9 | 42 | 5 | |
| cytochrome P450 family 11 subfamily A member 1 | CYP11A1 | 7 | 15 | ||
| nitric oxide synthase 2 | NOS2 | 5 | 12 | 1 | |
| nitric oxide synthase 1 | NOS1 | 2 | 6 | 1 | |
| peptidylglycine alpha-amidating monooxygenase | PAM | 1 | 1 | ||
| Cholinergic signaling pathway | |||||
| acetylcholinesterase | ACHE | 7 | 10 | ||
| cholinergic receptor nicotinic alpha 7 subunit | CHRNA7 | 4 | 15 | ||
| cholinergic receptor muscarinic 1 | CHRM1 | 3 | 5 | ||
| cholinergic receptor nicotinic alpha 3 subunit | CHRNA3 | 3 | 3 | ||
| cholinergic receptor nicotinic alpha 4 subunit | CHRNA4 | 3 | 6 | x | |
| choline O-acetyltransferase | CHAT | 2 | 4 | ||
| potassium voltage-gated channel subfamily Q member 1 | KCNQ1 | 0 | x | ||
| potassium voltage-gated channel subfamily Q member 2 | KCNQ2 | 0 | 2 | x | |
| potassium voltage-gated channel subfamily Q member 3 | KCNQ3 | 0 | x | ||
| Neuropeptide hormone activity | |||||
| corticotropin releasing hormone | CRH | 5 | 10 | 4 | |
| neuropeptide Y | NPY | 3 | 5 | ||
| adenylate cyclase activating polypeptide 1 | ADCYAP1 | 2 | 5 | ||
| cholecystokinin | CCK | 2 | 6 | 1 | |
| oxytocin/neurophysin I prepropeptide | OXT | 2 | 6 | 3 | |
| proopiomelanocortin | POMC | 2 | 3 | 1 | |
| thyrotropin releasing hormone | TRH | 1 | 2 | ||
| Dopaminergic signaling pathway | |||||
| dopamine receptor D2 | DRD2 | 4 | 25 | 2 | |
| dopamine receptor D1 | DRD1 | 3 | 13 | 3 | |
| dopamine receptor D3 | DRD3 | 1 | 1 | ||
| glutamate ionotropic receptor NMDA type subunit 2A | GRIN2A | 0 | x | ||
| glutamate ionotropic receptor NMDA type subunit 2B | GRIN2B | 0 | x | ||
| sodium voltage-gated channel alpha subunit 1 | SCN1A | 0 | x | ||
| Retrograde endocannabinoid signaling pathway | |||||
| fatty acid amide hydrolase | FAAH | 3 | 4 | ||
| cannabinoid receptor 1 | CNR1 | 2 | 2 | 2 | |
| gamma-aminobutyric acid type A receptor subunit alpha1 | GABRA1 | 0 | x | ||
| gamma-aminobutyric acid type A receptor subunit beta3 | GABRB3 | 0 | x | ||
| gamma-aminobutyric acid type A receptor subunit gamma2 | GABRG2 | 0 | x | ||