TABLE 1.

Features of the tumor associated antigens of HCC.

	GPC3	TLS11a target	EpCAM	PD-1
Expression in normal tissues	Low	None	Low	T cells
Expression in HCC tumors	High in about 70%	High	High	PD-L1/2 high
Function	Cancer cell proliferation, migration, metastasis	TLS11a-BiTE Inhibits HCC cells Hep3B and Huh-7	A CSC marker	Inhibiting T cells
McAb scFv or gRNA sequence	Not found	5-ACA GCATCC CCA TGT GAA CAATCGCATTGTGATTGTTA CGGTTTCCGCCTCATGGACG TGCTGTTTTTTTTTT-SH-3	Not found	PD-1-gRNA-1: GTCTGGGCGG TGCTACAACT; PD-1-RNA-2: GGCCAGGATG GTTCTTAGGT.
Ref	Wang Y. et al., 2018	Hu Z. et al., 2018	Zhang et al., 2014	Guo et al., 2018