TABLE 4.
Ongoing clinical trials involving GPC3 in HCC.
| Name | Trail ID | Phase | Study population | Intervention | Status |
| GC33 | japicCTI 101255 | I | HCC with no preferred treatment | GC33 | Unknown |
| GPC3 CAR-T | NCT02395250 | I | GPC3 + HCC patients | GPC3 CAR-T cells | Completed |
| GPC3 CAR-T | NCT02723942 | I/II | GPC3 + HCC patients | GPC3 CAR-T cells | Completed |
| GPC3 CAR-T | NCT03084380 | I/II | GPC3 + HCC patients | Anti-GPC3 CAR-T cells | Unknown |
| GLY CAR-T | NCT02905188 | I | Unresectable, recurrent metastatic GPC3 + HCC patients | GLYCAR T cells; Fludarabine | Recruiting |
| GPC3 CAR-T | NCT03884751 | I | Late stage HCC patients, unresectable | GPC3 CAR-T cells | Recruiting |
| GPC3-T2 CAR-T | NCT03198546 | I | GPC3 + advanced HCC patients | GPC3 and/or TGFβ targeting CAR-T cells | Recruiting |
| GPC3 CAR-T | NCT04506983 | I | GPC3 + HCC patients after failure or intolerance of first-line treatment | GPC3 CAR-T cells | Not yet recruiting |
| GPC3 CAR-T | NCT03146234 | Not Applicable | GPC3 + relapsed or refractory HCC patients | GPC3 CAR-T cells | Completed |
| GPC3 CAR-T | NCT04121273 | I | GPC3 + advanced HCC patients | GPC3 CAR-T cells | Recruiting |
| GPC3 CAR-T | NCT03980288 | I | Refractory or intolerant to current standard systemic treatment, GPC3 + advanced HCC patients | GPC3 CAR-T cells | Recruiting |
| GPC3 CAR-T | NCT02715362 | I/II | Unresectable, at least one prior standard of care chemotherapy, GPC3 + advanced HCC patients | TAI-GPC3 CART cells | Unknown |
| GPC3 CAR-T | NCT03130712 | I/II | GPC3 + advanced HCC patients with one prior standard of chemotherapy or surgery | GPC3 CART cells | Unknown |
| CT0180 Cells | NCT04756648 | I | GPC3 + advanced HCC patients | CT0180 humanized anti GPC3 autogenous T cell injection | Not yet recruiting |
| GPC3 CAR-T | NCT04121273 | I | GPC3 + advanced HCC patients | CAR-T cell immunotherapy | Recruiting |
| ECT204 T-Cell therapy (ARYA3) | NCT04864054 | I/II | GPC3 + adults advanced HCC patients with failure or intolerance of at least two different anti-HCC systemic agents | ECT204 T cells | Not yet recruiting |
| GC33 (RO5137382) | NCT01507168 | II | Unresectable advanced or metastatic GPC3 + HCC patients | GC33 | Completed |
| GPC3 CAR-T | NCT02959151 | I/II | GPC3 + advanced liver malignancy | CAR-T cell | Unknown |