Figure 2.

Functional modules and gene expression patterns. (a) Venn diagram illustrating unique and shared DEGs among five pairwise comparisons. (b) Venn diagram illustrating unique and shared DEGs among five functional modules. (c-g) K-means clustering of gene expression profiles of five functional modules M1 (c), M2 (d), M3 (e), M4 (f), and M5 (g). Cytokines, chemokines and their receptors (for M1-M5, identified using the ImmPort [24]) as well as GR targets implicated in immune responses (for M2-M5, in red, identified using the InnateDB [26], Harmonizome [25], and Ingenuity Pathway Analysis (IPA)) were indicated below corresponding modules