Figure 2.

Simplified view of the renin–angiotensin system (RAS) in the male reproductive system. Schematic cartoon illustrating the renin–angiotensin system in the male reproductive system. The main components of the pathway and the main functions of the ligands and receptors are shown. Renin enzyme cleaves its substrate Angiotensinogen to form the decapeptide AngI, which is in turn cleaved by ACEI to produce AngII(1−8). The functions of AngII(1−8) in male reproductive events are stimulated by the AngII type 1 receptor (AT1R). For the details, see the text. Full red arrows indicate the enzymatic action on the substrate. The blue block arrow indicates the inhibition of MasR on AT1R.