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. 2021 Jul 8;12:670746. doi: 10.3389/fgene.2021.670746

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Copyright © 2021 Li, Xu, Li, Yang, Qiao, Wang, Wang, Guo and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Intersection analysis of top genes that derived protein-protein interaction (PPI) network and univariate COX processing. (A) PPI network constructed with the nodes with interaction confidence value > 0.90. (B) The top 30 genes ordered according to the number of adjacent nodes (from large to small). (C) Univariate COX regression analysis with DEGs. Listing the top 30 significant factors with p < 0.05 (from small to large). (D) The common factors shared by the top 30 genes in PPI and top 30 significant factors in univariate COX.