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. Author manuscript; available in PMC: 2021 Jul 22.
Published in final edited form as: Adv Ther (Weinh). 2020 Feb 3;3(3):1900164. doi: 10.1002/adtp.201900164

Figure 8.

Figure 8.

a) There are three distinct building blocks in FAMEs: a myristoyl group, an ordered β-sheet-forming domain, and a disordered ELP domain. The myristoyl group and β-sheet-forming domain together forms a peptide amphiphile (PA). b) Below Tt (T < Tt), cylindrical micelles are formed due to the attractive forces of the PA core and the repulsive force of the hydrated ELP corona (stage 1). Above Tt (Tc > T > Tt) the dehydrated ELP domain undergoes an LCST phase transition into a liquid-like coacervate and forms spherical droplets (stage 2). Above Tc the ELP gets further dehydrated decreasing repulsion between the coronas that drive macroscale self-assembly (stage 3). Reproduced with permission.[178] Copyright 2018, Springer Nature.