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. Author manuscript; available in PMC: 2021 Jul 22.
Published in final edited form as: Adv Ther (Weinh). 2020 Feb 3;3(3):1900164. doi: 10.1002/adtp.201900164

Table 1.

Self-assembling behavior of ELP-hybrid materials.

Synthetic motif ELP sequence Method of appendment Self-assembling behavior References
Palmitoyl chain (VPGXG)3; X = A/I/V Synthetic: Fmoc-chemistry Nanofiber [159]
Myristoyl chain (VPGXG)40–120; X = A:V 9:1 Recombinant: PTM Spherical micelle [160]
Peptide amphiphile (VPGVG)40 Recombinant: PTM Dynamic: worm-like to nanofiber [161]
Peptide amphiphile [(VPGVG VPGEGVPGVG VPGVG)10-(VGIPG)60]2-[(VPGIG)10-AVTGRGDSPASS(VPGIG)10]2 Physical mixing Dynamic: membrane to 3D tube [162]
Cholesterol [G(V8/A2)GVP]10GKG] Recombinant: PTM Ellipsoid micelle [161]
DSPE-PEG (VPGVG)20
(VPGVG)128 		Synthetic: NHS-chemistry Liposomes [163,164]
Stearyl (VPGVG)2–6 Synthetic: coupling chemistry Liposomes [165–167]
p-azidophenyl alanine (VPGVG)20 & (VPGVG)20-(VPGSG)80 Recombinant: UAA technology Nano to microscale gel particle [168]
PEG (VPGXG)40–130; X = V:L:G 5:2:3 Synthetic: SPAAC Spherical micelle [169]
PAA (VPGVG)2 Synthetic: Cu-catalyzed click reaction Spherical aggregate [170]
PBLG [(VPGVG)(VPGMG)(VPGVG)2]10 Synthetic: ROP Spherical micelle, worm-like, vesicle [171]
Silica (VPGVG)60-(VPGXG)60; X = A:G 1:1 Synthetic: Silification Clustered sphere to discrete particle [172]

Self-assembly behavior depends on extrinsic parameters like temperature, concentration, solvent, self-assembling technique, etc. These parameters have been described in the text but not in this table.