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. 2021 Jul 8;12:714340. doi: 10.3389/fimmu.2021.714340

Figure 1.

Figure 1

Formation and activation of NLRP3 inflammasome. The effect of extracellular stimulating factors activates the intracellular NF-κB pathway. The activation of NF-κB pathway promotes the expression of inflammasome NLRP3, IL-1β, and IL-18. The activation of the inflammasome NLRP3 promotes the activation of caspase-1, and the activated caspase-1 promotes the maturation of IL-1β and IL-18, which are then secreted into the extracellular to exert biological effects. NLRP3, nod like receptor protein 3; IL, interleukin.