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Mechanism of NLRP3 inflammasome in diabetic nephropathy. High glucose stimulation activates NLRP3 inflammasome mainly through K+ outflow, ROS and lysosomal rupture. TNXIP binding to NLRP3 is a pivotal mechanism of NLRP3 inflammasome activation. The activation of NLRP3 inflammasome will lead to podocyte lose, glomerulosclerosis and tubulointerstitial fibrosis. NLRP3, nod like receptor protein 3; ROS, reactive oxygen species; EMT, epithelial mesenchymal transition.
