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. 2021 Jul 8;12:691407. doi: 10.3389/fphys.2021.691407

FIGURE 2.

FIGURE 2

PGE2-mediated proANP31–67 cardiac, renal and metabolic mechanisms of action. PGE2, Prostaglandin E2; EP1–4, PGE2 receptors (coupled to Gq); AA, Arachidonic acid; COX-1/2, Cyclooxygenase-1 and –2; PGH2, Prostaglandin H2; PGES, Prostaglandin E synthase; PLC, Phospholipase C; Pi3K, Phosphoinositide 3-kinases; AC, Adenylate cyclase; Ca2+, Calcium ion; AKT, protein kinase B; cAMP, Adenosine 3′,5′-cyclic monophosphate; PKA, protein kinase A; SMAD2–4, SMAD (Mothers against decapentaplegic) family member 2, 3, and 4; PPARγ, Peroxisome proliferator-activated receptor gamma.