. 2021 Jul 8;11:698197. doi: 10.3389/fonc.2021.698197

Table 1.

Characteristics of studies and the diagnostic power of miRNAs.

No.	Author	Country	Year	Sample size		Sample	miRNA	Expression	Diagnostic power
No.	Author	Country	Year	MM	HC	Sample	miRNA	Expression	AUC	SENC	SPEC
1	Li J (14)	China	2020	23	18	serum	miR-134-5P	↑	0.812	0.870	0.667
2						serum	miR-107	↑	0.766	0.564	0.889
3						serum	miR-15a-5p	↑	0.804	0.870	0.610
4	Gupta N (15)	India	2019	30	30	serum	miR203	↓	0.930	0.833	0.833
5						serum	miR143	↓	0.864	0.767	0.767
6						serum	miR144	↓	0.784	0.733	0.733
7						serum	miR199	↓	0.900	0.800	0.800
8	Shen X (16)	China	2017	71	46	serum	miR-4449	↑	0.885	0.789	0.913
9	JIANG Y (17)	China	2018	35	20	plasma	miR-125b-5p	↑	0.954	0.860	0.960
10						plasma	miR-490-3p	↑	0.866	0.600	0.850
11	Qu X (18)	China	2014	40	20	plasma	miR-483-5p	↑	0.745	0.580	0.900
12						plasma	miR-20a	↓	0.740	0.630	0.850
13	Kubiczkova L (19)	Czech	2013	103	30	serum	miR-744	↓	0.715	0.728	0.667
14						serum	miR-130a	↓	0.722	0.575	0.900
15						serum	miR-34a	↑	0.790	0.777	0.700
16						serum	let-7d	↓	0.804	0.641	0.867
17						serum	let-7e	↓	0.829	0.888	0.633
18	Yoshizawa S (20)	Japan	2011	62	21	plasma	miR-92a	↓	0.981	0.919	0.991
19	Jones Cl (21)	UK	2012	24	13	serum	miR-720	↑	0.911	0.872	0.923
20						serum	miR-1308	↓	0.892	0.821	0.923
21	Hao M (22)	China	2015	108	56	Serum	miR-4254	↑	0.926	0.793	0.985
22						Serum	miR-19a	↓	0.910	0.773	0.897
23						Serum	miR-92a	↓	0.830	0.724	0.869
24						Serum	miR-135b-5p	↑	0.810	0.667	0.833
25						Serum	miR-214-3p	↑	0.720	0.625	0.833
26						Serum	miR-3658	↑	0.720	0.714	0.667
27						Serum	miR-33b	↑	0.630	0.633	0.815
28	Y u J (13)	China	2014	40	30	serum	miR-202	↓	0.711	0.800	0.600
29	Sevcikova S (23)	Czech	2013	91	30	Serum	miR-29a	↑	0.832	0.880	0.700
miRNA cluster
30	Kubiczkova L (19)	Czech	2013	103	30	serum	miR-34a+let7e	N/A	0.898	0.806	0.867
31	Jones Cl (21)	UK	2014	24	13	serum	miR-1308/miR-720	N/A	0.986	0.974	0.923
32	Hao M (22)	China	2015	108	56	Serum	miR-4254/miR-19a	N/A	0.950	0.917	0.905

AUC, area under the curve; HC, health control; MM, multiple myeloma; N/A, Not applicable; SENS, sensitivity; SPEC, specificity; ↑, increase; ↓, decrease.