Table 5.
Circulating miRNAs in MM, MGUS, and SMM.
| Author | Sample size | miRNAs | Distributional or differential diagnostic data | |
|---|---|---|---|---|
| MM vs MGUS | MM | MGUS | ||
| Li J (14) | 23 | 16 | miR-134-5P | ROC: AUC=0.489 (p=0.909) |
| miR-107 | ROC: AUC=0.427 (p=0.441) | |||
| miR-15a-5p | ROC: AUC=0.557 (p=0.549) | |||
| miR-134-5P + miR-107 + miR-15a-5p | ROC: AUC=0.550 (p=0.095) | |||
| mir-107 + mir-15a-5p + Hb | ROC: AUC=0.954 (p=0.000), sensitivity=0.913, specificity=0.917 | |||
| Kubiczkova L (19) | 103 | 57 | miR-744 | MM: 473, MGUS: 371, fold change between MM/MGUS: 1.27 |
| miR-130a | MM: 5618, MGUS: 6232, fold change between MM/MGUS: 0.90 | |||
| miR-34a | MM: 176, MGUS: 192, fold change between MM/MGUS: 0.92 | |||
| let-7d | MM: 1944, MGUS: 1863, fold change between MM/MGUS: 1.04 | |||
| let-7e | MM: 4222, MGUS: 3521, fold change between MM/MGUS: 1.20 | |||
| Yoshizawa S (20) | 62 | 22 | miR-92a | One-way analysis of variance: p=0.0005 |
| Jones Cl (21) | 24 | 15 | miR-720 | ROC: AUC=0.528 (p=0.773) |
| miR-1308 | ROC: AUC=0.572 (p=0.453) | |||
| miR-1246 | ROC: AUC=0.628 (p=0.184) | |||
| miR-1308/miR-720 | ROC: AUC=0.597 (p=0.312) | |||
| miR-1246/miR-1308 | ROC: AUC=0.725(P< 0.05), sensitivity=0.792, specificity=0.667 | |||
| MM vs SMM | MM | SMM | ||
| Yoshizawa S (20) | 62 | 8 | miR-92a | One-way analysis of variance: p=0.0496 |
| Zhang Z (25) | 20 | 20 | let-7d-5p | Mann‐Whitney U test and one‐way analysis of variance: p=0.354 |
| miR-20a-5p | Mann‐Whitney U test and one‐way analysis of variance: p=0.402 | |||
| MGUS vs SMM | MGUS | SMM | ||
| Yoshizawa S (20) | 22 | 8 | miR-92a | One-way analysis of variance: p=0.2959 |
| Manier S (24) | 4 | 4 | miR-107 | p < 0.05 |
| miR-92a | p < 0.05 | |||
| miR-125a | p < 0.05 | |||
AUC, area under the curve; Hb, hemoglobin; MGUS, monoclonal gammopathy of undetermined significance; MM, multiple myeloma; ROC, receiver operator characteristic curve; SMM, smoldering multiple myeloma.