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. 2021 Jul 8;12:687947. doi: 10.3389/fphys.2021.687947

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Copyright © 2021 Guo, Jia, Tu, Jin, Guo, Song, Wu, Bao and Fan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Altered Jagged1-Notch1 signaling with baseline neovascularization in T2DM. (A–C) The expression of VEGF-A, Ang-2, Jagged1, Notch1, NICD, and Hes1 in the cortex was assessed by Western blot (n = 3 per group). (D–I) The expression of Jagged1/Notch1/Hes1 and CD31 was assessed by immunofluorescence staining in the cortex (Magnification ×200. Scale bar = 100 μm) and the positive cells of Jagged1/Notch1/Hes1 and CD31 were calculated (n = 3 per group). *p < 0.05 vs. NC group, **p < 0.01 vs. NC group, ***p < 0.001 vs. NC group, ****p < 0.0001 vs. NC group.