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. 2021 Jul 8;12:687947. doi: 10.3389/fphys.2021.687947

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Copyright © 2021 Guo, Jia, Tu, Jin, Guo, Song, Wu, Bao and Fan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Suppressed Jagged1-Notch1 signaling with hampered angiogenesis after acute ischemic stroke in T2DM. (A–C) The expression of Ki67 and CD31 was assessed by immunofluorescence staining in ischemic penumbra (Magnification * 200. Scale bar = 100 μm) and the positive cells of Ki67 and CD31 were calculated (n = 3 per group). (D,E) The gene expression of Jagged1, Notch1, Hes1, and Hes5 was showed in NDI and DI group. (F,G) The expression of Jagged1, Notch1, NICD, and Hes1 protein were calculated in NDI group and DI group. *p < 0.05 vs. sham group, **p < 0.01 vs. sham group, ***p < 0.001 vs. sham group, ****p < 0.0001 vs. sham group.