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Smoothed restricted cubic spline plot of the adjusted log hazard ratio of death in patients receiving adjuvant (A), neoadjuvant (B), and no chemotherapy (C). The predicted hazards ratios were estimated from a proportional hazards model adjusting for covariates. The light dotted curves represent the 95% confidence intervals about the predicted odds ratio. The black dots correspond to the location of 4 knots used in the model. The dashed vertical line indicates the bootstrapped minimum.
