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. 2021 Jul 8;12:649336. doi: 10.3389/fphys.2021.649336

TABLE 4.

Laboratory findings at admission in kidney diseases based on renal biopsies comparing 2020 with 2019.

2020 2019 P value
ANCA GN
Median creatinine (IQR) – mg/dL 3.26 (1.2–3.96) 2.28 (1.12–4.8) 0.9111
Median BUN (IQR) – mg/dL 33 (19–39) 43 (24.8–75.8) 0.1219
Median proteinuria (IQR) – mg/L 812 (476–3584) 1334 (549–1898) 0.7375
Median uACR (IQR) – mg/g 1222 (376–4925) 703 (217–1047) 0.1645
Median hemoglobinuria– no. (%) 6 (66.7) 17 (100) 0.0114
Acute interstitial nephritis
Median creatinine (IQR) – mg/dL 1.07 (0.975–2) 2.78 (2.1–8.55) 0.0091
Median BUN (IQR) – mg/dL 20 (16.5–46) 48 (24.3–80.8) 0.0343
Median proteinuria (IQR) – mg/L 459 (353–2357) 207 (129–859) 0.0268
Median uACR (IQR) – mg/g 1313 (267–2099) 53.3 (30–654) 0.0294
Median hemoglobinuria– no. (%) 7 (87.5) 5 (50) 0.0935
IgA nephropathy
Median creatinine (IQR) – mg/dL 1.5 (0.935–3.49) 2.18 (1.28–4.87) 0.5726
Median BUN (IQR) – mg/dL 26.5 (20.5–73.3) 35.5 (17.8–56) 0.9844
Median proteinuria (IQR) – mg/L 563 (256–1380) 1252 (792–2168) 0.2743
Median uACR (IQR) – mg/g 399 (105–1867) 933 (298–1755) 0.5726
Median hemoglobinuria– no. (%) 6 (75) 9 (90) 0.3961
Diabetic nephropathy
Median creatinine (IQR) – mg/dL 1.29 (0.76–1.52) 2.5 (1.98–4.24) 0.0047
Median BUN (IQR) – mg/dL 17 (13–19) 46 (31.5–77.5) 0.0032
Median proteinuria (IQR) – mg/L 2536 (214–5755) 623 (165–2861) 0.6426
Median uACR (IQR) – mg/g 2167 (135–3371) 491 (31.9–3737) 0.6426
Median hemoglobinuria– no. (%) 4 (57.1) 6 (46.2) 0.6392
FSGS
Median creatinine (IQR) – mg/dL 1.68 (1.24–2.47) 1.59 (0.758–2.96) 0.6359
Median BUN (IQR) – mg/dL 32 (20–62.5) 28 (16.5–53.5) 0.5519
Median proteinuria (IQR) – mg/L 368 (336–1104) 750 (159–2409) 0.5846
Median uACR (IQR) – mg/g 226 (34.4–694) 1175 (309–4218) 0.1718
Median hemoglobinuria– no. (%) 4 (66.7) 7 (50) 0.4924
Hypertensive nephropathy
Median creatinine (IQR) – mg/dL 2.69 (1.32–3.36) 1.49 (1.2–2.2) 0.2105
Median BUN (IQR) – mg/dL 48 (25–49) 31 (19.5–64.5) 0.4066
Median proteinuria (IQR) – mg/L 860 (258–3000) 132 (50.6–476) 0.0093
Median uACR (IQR) – mg/g 300 (112–1948) 29 (13.5–518) 0.0813
Median hemoglobinuria– no. (%) 6 (85.7) 1 (12.5) 0.0046
Lupus nephritis
Median creatinine (IQR) – mg/dL 1.91 (0.73–2.12) 0.85 (0.655–1.37) 0.1738
Median BUN (IQR) – mg/dL 22 (12–31) 13 (11.5–18) 0.1620
Median proteinuria (IQR) – mg/L 372 (169–765) 1417 (67.8–2584) 0.5350
Median uACR (IQR) – mg/g 106 (68.4–2505) 1337 (30–3337) 0.7104
Median hemoglobinuria– no. (%) 5 (71.4) 4 (50) 0.3980

For group comparisons, the Mann-Whitney U-test was used to determine differences in medians. Non-parametric between-group-comparisons were performed with Pearson’s Chi-square test. Bold indicates statistically significant values at group level. ANCA, anti-neutrophil cytoplasmic antibodies; BUN, blood urea nitrogen; CRP, C-reactive protein; FSGS, focal segmental glomerulosclerosis; GN, glomerulonephritis; IgA, immunoglobulin A; IQR, interquartile range; No., number; uACR, albumin:creatinine ratio.