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. 2021 Jul 8;12:692832. doi: 10.3389/fmicb.2021.692832

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Copyright © 2021 Wen, Chen, Luo, Liu, Guo, Wei, Gu, Gu, Ning and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Infiltration of Jagged1⁺ macrophages is higher in the gastric mucosa of H. pylori⁺ gastritis patients. (A) Gastric mucosa tissues from H. pylori^– and H. pylori⁺ gastritis patients were double-immunofluorescent stained with anti-Jagged1 antibody (green) and anti-CD68 antibody (red), and nuclei were stained with DAPI (blue). A merged figure of macrophages is also shown. The yellow arrows indicate Jagged1⁺ CD68⁺ macrophages. Images were observed under a fluorescence microscope (200×). Representative images of the gastric mucosa of H. pylori^– (n = 6) or H. pylori⁺ (n = 10) gastritis patients were shown. The results represent three independent experiments. (B) Quantification of the number of CD68⁺ Jagged1⁺ cells in the gastric mucosa of H. pylori^– or H. pylori⁺ (n = 10) gastritis patients. The data are presented as the mean ± SD of three independent images of each patient. **p < 0.01.