Fig 1. General principles of network and Cmap-based repurposing approaches.

A) Network-based repurposing. Disease-related proteins and drug targets are mapped into a network of protein-protein-interactions (PPI). Drugs are prioritized according to their distance to disease-related proteins. B) Supportive Cmap-based repurposing. In those supportive analyses, disease-related as well as drug induced gene expression states are compared in order to identify drugs eliciting reverse profiles compared to those found in the disease.