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. 2021 Jul 22;16(7):e0254374. doi: 10.1371/journal.pone.0254374

Fig 4. Druggable interactome of proteins contributing to lung inflammation in COVID-19.

Fig 4

Extraction of the interactome encompassing proteins predicted to contribute to COVID-19 evolution towards a cytokine storm. Following SARS-CoV-2 infection of lung tissues and ensuing activation of innate and adaptive immune cells, different categories of proteins represent potential therapeutic targets to prevent or slow down lung inflammation associated with severe COVID-19. The latter include Alarmins, as well as cytokines, chemokines and selected proinflammatory factors associated with the Cytokine storm. For clarity, this figure only displays the disease related proteins (Alarmins & Cytokine storm) identified in our model, our top ranking repurposed drugs as well as some functional partners. The latter represent additional proteins needed in order to form a minimal principal component graph.