TABLE 2.

List of the overrepresented pathway formatted with the variant-containing-genes identified in patients with non-syndromic cleft palate only (NSCPO).

Pathway ID	Term description	Observed gene count	Background gene count	False discovery rate	Matching proteins in your network
hsa00670*	One carbon pool by folate	6	20	3.63e-11	MTHFD1, FTCD, TYMS, SHMT1, MTR, MTHFR
hsa01523*	Antifolate resistance	3	31	0.00038	TYMS, SHMT1, MTHFR
hsa01100	Metabolic pathways	8	1250	0.0027	MTHFD1, FTCD, TYMS, SHMT1, ACACB, POMGNT2, MTR, MTHFR
hsa04974	Protein digestion and absorption	3	90	0.0039	COL11A1, COL11A2, COL2A1
hsa04330	Notch signaling pathway	2	48	0.0262	CREBBP, JAG2
hsa01230*	Biosynthesis of amino acids	2	72	0.0460	SHMT1, MTR
hsa04520	Adherens junction	2	71	0.0460	CDH1, CREBBP
hsa05200	Pathways in cancer	4	515	0.0460	LRP6, CDH1, CREBBP, JAG2

^∗Pathway found only in NSCPO.