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. 2021 Jul 22;39(6):934–965. doi: 10.1016/j.clindermatol.2021.07.001

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Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig 22 — Pathophysiologic mechanisms underlying severe COVID-19 including the role of Mannan Binding lectin and alternative pathway complement-mediated microvascular injury and the blunted interferon response. COVID-19, coronavirus disease 2019.