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. 2021 Jun 30;12:702779. doi: 10.3389/fmicb.2021.702779

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Copyright © 2021 Garcia-Rubio, Hernandez, Clear, Healey, Shor and Perlin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vitro echinocandin hyper-susceptibility of yps1Δ, ypk2Δ, and slt2Δ was confirmed in the ATCC90030 strain background. (A) Minimum inhibitory concentration (MIC) susceptibility testing to caspofungin and micafungin showed that the deletion mutants had lower or identical MIC-values than the wild-type parental strain. Echinocandin concentrations are shown in μg/ml. (B) The in vitro tolerance assay confirmed that the mutants exhibited reduced drug tolerance compared to the parental ATCC90030 strain. Statistical significance was calculated using an unpaired t-test; p-value ≤ 0.05 is indicated with an asterisk (*), p-value > 0.05 is indicated as n.s. (not significant).