It is necessary to apply dexamethasone as a therapy in critical COVID-19 patients, but its adverse side effects cannot be ignored.

Through a variety of molecular pathways, dexamethasone can interfere with normal organ functions and cause numerous clinical manifestations, intensifying the risk and severity of sequelae of COVID-19 disease, such as osteonecrosis of the femoral head, hypertension and diabetes.

Regular follow-up and evaluation of physical conditions in accordance with the time line are crucial for COVID-19 patients who have received dexamethasone treatment.