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. 2021 Jul 21;218(8):e20200938. doi: 10.1084/jem.20200938

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© 2021 Hisata et al.

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Figure 1. — Loss of expression of key endothelial cell marks is a hallmark of COPD in human lung tissue and correlates with disease severity.(A and B) In silico analyses of microarray and RNA-seq datasets from the LGRC of VEGFR2/KDR (A) and VEGFA expression (B) in nonsmoker control, smoker control, COPD GOLD1/2 (mild), and COPD GOLD3/4 (severe) lungs. (C and D) Correlation between the expression of VEGFR2/KDR and physiological parameters % FEV₁ (C) and % DLCO (D). (E) Correlation between VEGFR2/KDR expression and severity of emphysema determined by chest computed tomography (% emphysema). **, P < 0.01; ****, P < 0.0001.