Table 8.

Effect of topical application of ointment prepared from 80% hydromethanolic crude extract of B. abyssinica leaves on wound area contraction (mm²) in burn wound model in mice.

Days	Simple ointment	Methanolic crude extract 5% (w/w)	Methanolic crude extract 10% (w/w)	Nitrofurazone 0.2% (w/v)
2	282.33 ± 4.89	272.17 ± 5.24	272.00 ± 5.05	271.83 ± 4.73
4	254.33 ± 5.10	237.17 ± 4.21	233.17 ± 4.48a1	232.00 ± 4.12a1
6	227.00 ± 3.69	208.00 ± 3.25a1c1d2	190.67 ± 4.56a3b2	186.83 ± 4.44a3b2
8	195.50 ± 4.46	167.67 ± 3.14a1c1d2	150.67 ± 3.25a3b1	144.00 ± 4.07a3b2
10	165.83 ± 3.83	134.83 ± 2.77a3c2d3	117.83 ± 1.54a3b2	113.50 ± 2.77a3b3
12	135.00 ± 3.77	99.00 ± 3.07a3c1d2	86.33 ± 3.20a3b2	83.50 ± 1.93a3b2
14	105.17 ± 3.79	62.50 ± 3.11a3c2d2	50.17 ± 2.40a3b2	48.00 ± 1.83a3b2
16	76.67 ± 2.49	33.67 ± 2.99a3d2	26.00 ± 1.39a3	21.83 ± 1.56a3b2
18	49.50 ± 3.63	9.83 ± 1.47a3d2	3.33 ± 0.76a3	1.33 ± 0.71a3b2
20	17.67 ± 3.03	0.50 ± 0.34a3	0.00 ± 0.00a3	0.00 ± 0.00a3
22	3.50 ± 1.23	0.00 ± 0.00a2	0.00 ± 0.00a2	0.00 ± 0.00a2
24	0.00 ± 0.00	0.50 ± 0.34	0.00 ± 0.00	0.00 ± 0.00

Data are expressed as mean ± SEM; n = 6, a, compared with simple ointment; b, compared with crude methanolic extract 5% (w/w); c, compared with crude methanolic extract 10% (w/w) ointment; d, compared with nitrofurazone 0.2% (w/v) ointment. 1, p < 0.05; 2, p < 0.01; 3, p < 0.001.