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. 2021 May 6;40(29):4746–4758. doi: 10.1038/s41388-021-01800-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Western blot analysis of THP1 cells treated for 24 h without compound or with 1 μM AT or 0.5 μM HA. B, C Volcano plots showing gene expression changes (log2-fold change versus -log10 pval) of AT- and HA-treated THP1 cells. Genes up- or down-regulated four-fold or more (p < 0.05) are shown as red dots. D Real-time PCR of selected genes up- or down-regulated by AT or HA. Data are derived from three biological replicates. Bars indicate the log2-fold up- or down-regulation and standard deviation of the indicated genes. Known MYB-regulated genes are marked with asterisks. E–H GSEA of the AT- and HA-induced gene expression signature and genes repressed or activated by MYB in THP1 cells. I Decreased MYC and GFI1 expression in THP1 cells after treatment for 2 and 4 h with AT (1 μM), AMA (1 μM), or HA (0.5 μM). Asterisks indicate statistical significance (*p < 0.05, **p < 0.01, ***p < 0.001, Student’s t test).