Table 1.
Compound | CAS number | Solvent* | Concentrations** | RSG |
---|---|---|---|---|
KBrO3 | 7758-01-2 | H2O | 0.313 mM | 90 |
0.625 mM | 85 | |||
1.25 mM | 78 | |||
2.5 mM | 40 | |||
MMS | 66-27-3 | DMSO | 5 µM | 98 |
10 µM | 85 | |||
20 µM | 80 | |||
40 µM | 58 | |||
EMS | 62-50-0 | DMSO | 0.5 µM | 90 |
5 µM | 84 | |||
50 µM | 77 | |||
100 µM | 40 | |||
BPDE | 55097-80-8 | DMSO | 0.025 µM | 93 |
0.05 µM | 83 | |||
0.1 µM | 70 | |||
0.2 µM | 50 | |||
H2O2 | 7722-84-1 | PBS | 125 µM | 92 |
250 µM | 87 | |||
500 µM | 79 | |||
CisPt | 15663-27-1 | H2O | 0.83 µM | 100 |
1.66 µM | 100 | |||
3.33 µM | 80 | |||
6.66 µM | 39 | |||
13.33 µM | 12 | |||
Mit. C | 50-07-7 | Medium | 0.006 µM | 98 |
0.03 µM | 95 | |||
0.15 µM | 82 | |||
0.3 µM | 50 | |||
Triton X-100 | 9002-93-1 | H2O | 0.03 mM | 60 |
0.1 mM | 7 | |||
DMSO | 67-68-5 | Medium | 1% | 100 |
2% | 95 | |||
4% | 83 | |||
8% | 80 |
*The final solvent concentration was 1% in all cases. **The three lowest concentrations of each compound were employed for the enzyme-modified comet assay. The same three concentrations and the highest one (the two highest in the case of CisPt) of each compound were used for the comet assay modified for ICL detection (except for H2O2 and Triton X-100)