Table 1.
Basic characteristics of the study population stratified by the use of HMGRIs
| All N = 3157 |
Use of HMGRIs N = 229 |
No use of HMGRIs N = 2928 |
|
|---|---|---|---|
| Age (years) * | 59.0 ± 7.5 | 61.9 ± 6.9 | 58.7 ± 7.5 |
| Women | 1675 (53.1) | 118 (51.5) | 1557 (53.2) |
| Body mass index (kg/m2) * | 27.6 ± 4.3 | 27.9 ± 3.4 | 27.6 ± 4.4 |
| Diabetes | 359 (11.4) | 41 (17.9) | 318 (10.9) |
| Diastolic blood pressure (mmHg) * | 81.2 ± 10.6 | 80.4 ± 9.2 | 81.3 ± 10.7 |
| Systolic blood pressure (mmHg) * | 131.4 ± 19.9 | 133.6 ± 17.7 | 131.3 ± 20.1 |
| Antihypertension medication | 981 (31.1) | 127 (55.5) | 854 (29.2) |
| LDL cholesterol (mg/dL) * | 146.3 ± 35.7 | 129.9 ± 30.2 | 147.6 ± 35.8 |
| HDL cholesterol (mg/dL) * | 59.3 ± 16.9 | 58.7 ± 17.4 | 59.3 ± 16.8 |
| Triglycerides (mg/dL) † | 121.0 (87.0; 174.0) | 138 (100.0; 204.0) | 120 (86; 171) |
| Total cholesterol (mg/dL) * | 230.9 ± 38.3 | 217.2 ± 34.9 | 232.0 ± 38.3 |
| Non-smoker | 1377 (43.6) | 103 (45.0) | 1274 (43.5) |
| Past smoker | 1080 (34.2) | 80 (34.9) | 1000 (34.2) |
| Current smoker | 700 (22.2) | 46 (20.1) | 654 (22.3) |
| SES (≤ 13 years) | 1086 (34.4) | 82 (35.8) | 1004 (34.3) |
| CAC score at baseline † | 7.5 (0.0; 98.8) | 61.4 (2.8; 279.8) | 6.2 (0; 84) |
| CAC score at first follow-up † | 27.9 (0; 202.2) | 142.9 (22.4; 561.9) | 24 (0; 182.3) |
| Slow progression of CAC | 392 (12.4) | 16 (7.0) | 376 (12.8) |
| Expected progression of CAC | 2147 (68.0) | 143 (62.5) | 2004 (68.4) |
| Rapid progression of CAC | 618 (19.6) | 70 (30.6) | 548 (18.7) |
| Weighted GRS * | 0.0498 ± 0.005 | 0.0497 ± 0.0047 | 0.0499 ± 0.005 |
LDL low-density lipoprotein, HDL high-density lipoprotein, SES socioeconomic status, CAC coronary artery calcification, GRS genetic risk score. Data are given as number (percentage) unless otherwise indicated. * Data are given as the mean ± SD. † Data are given as the median (Q1; Q3).