Table 3.

Groups used in ICV colchicine-induced dementia (chronic model) in rats

S.No	Group (n = 8)	Model induction	Treatment
I	SC	-	Normal saline
II	ACSF	ACSF only	Normal saline
III	COL	Colchicine 15 µg (ICV) induced dementia (chronic model)	Normal saline
IV	COL + ORSM		Rivastigmine (2.5 mg/kg, p.o.)
V	COL + INRSM		Rivastigmine (2.0 mg/kg, IN)
VI	COL + INRL		Rivastigmine liposomes (2.0 mg/kg, IN)

SC sham control, ACSF artificial cerebrospinal fluid, COL colchicine, ORSM oral pure rivastigmine, INRSM intranasal pure rivastigmine, INRL intranasal liposomal formulation of rivastigmine