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. 2021 Jul 22;7:17. doi: 10.1038/s41514-021-00069-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Manhattan-style plots of local genetic correlation and covariance (top) and local SNP heritability (bottom) for HDiff and AD. Local genetic correlation corresponds to genomic regions that contribute significantly to the genome-wide genetic correlation. Local genetic covariance corresponds to the similarity between HDiff and AD driven by genetic variations localized at a specific region in the genome. b Heritability enrichment (% of heritability/% of SNP) values in HDiff and AD SNPs located in each of 27 genomic functional elements. Error bars represent jackknife standard errors around the estimates of enrichment. Key: CTCF CCCTC-binding factor, DGF digital genomic footprint, DHS DNase I hypersensitive site, TFBS transcription factor binding site, TSS transcription start site, UTR untranslated region. Single, double, and triple asterisks indicate significance at P < 0.05 after Bonferroni-correction in HDiff, AD, and both HDiff and AD, respectively.