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. 2021 Jul 22;12:4451. doi: 10.1038/s41467-021-24737-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Representative screenshots of different genomic regions in which DRIPc-seq signal of detected peaks (average coverage n = 2) from WT (blue), hpr1-aid (red), and sen1-aid (green) cells. The H2AP ChIP-seq signal from hpr1-aid (dark red) and sen1-aid (dark green) subtracting the WT signal is also shown. b Metaplot analysis of DRIPc-seq peaks ±5 Kb and H2AP ChIP-seq signal detected in WT (orange), hpr1-aid (gray), and sen1-aid (yellow) cells. Other details as in (a). c Metaplot analysis of DRIPc-seq peaks ±5 Kb and H2AP ChIP-seq signal of specific peaks in hpr1-aid cells and sen1-aid cells with respect to the WT. Other details as in (b). d Distribution of H2AP ChIP-seq signal (average coverage) along early ARS ± 10 Kb from WT (blue), hpr1-aid (red), and sen1-aid (green) cells. e Percentage of genes R-loop-enriched in WT (blue), hpr1-aid specific (red), sen1-aid specific (green), and common enriched (gray) that would collide with the replication forks coming from early ARS in head-on (top) or codirectional (bottom) orientation. The P values were calculated by the chi-square test one-sided, one degree of freedom.