Fig. 1. Design of an MPRA library to identify candidate functional SNPs in MDD loci.

A Table of GWAS studies and number of loci covered in the MPRA library. B Flow chart of design and prioritization process. C Brain and neural transcriptional-regulatory predictive annotation overlap with SNPs included in MPRA library. Fraction and number of SNPs in designed MPRA library intersecting each transcriptional-regulatory predictive annotation type. D The manual prioritization process was not LD biased. The subset of prioritized SNPs are spread over LD space similarly to the full set of screened SNPs. E Schematic of library construction and delivery. Panel adapted from [50].