. 2021 Jul 22;4:898. doi: 10.1038/s42003-021-02183-1

Table 3.

Non-human primate upper gastrointestinal model parameters.

Parameter/state variable	Description	Value (range)	Initial value	Units	Source
t	Time	-	-	min
f	Fraction of stomach contents remaining (relative to initial state)	(0.0–1.0)	1	Unitless
$β$	Gastric emptying curve shape parameter	1.12	-	Unitless	Human parameter
t_1/2	Half gastric emptying time	24.5	-	min	Kondo 2003a⁴⁰
Phe_St	Stomach Phe content	-	1513.41	μmol	Isabella 2018¹⁴
TCA_St	Stomach TCA content	-	0	μmol
Cells_St	Stomach SYNB1618 content	-	Dose-dependent	Cells
pH_St	stomach pH	(1.97–8.0)	-	Unitless	Chen 2008⁴¹, Kondo 2003b⁴²
pH₀	Initial stomach pH	6.0	-	Unitless	Chen 2008⁴¹, Kondo 2003b⁴²
pH_{St_min}	Minimum gastric pH	1.97	-	Unitless	Kondo 2003b⁴²
k_pH	Gastric pH decay constant	0.004	-	min⁻¹	Kondo 2003b⁴²
Phe_SI	Small intestinal Phe content	-	7.7	μmol	Estimated from SI volume
TCA_SI	Small intestinal TCA content	-	0	μmol
Cells_SI	Small intestinal SYNB1618 content	-	0	Cells
pH_SI	Small intestinal pH	5.8	-	Unitless	Hatton 2015⁴
Vol_St	Fasted stomach volume	17.0	-	mL	Unpublished NHP study
Vol_SI	Small intestinal volume	13.7	-	mL	Unpublished NHP study
$λ$	Small intestinal absorption rate	0.1019	-	min⁻¹	Human parameter