Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 22;12:4452. doi: 10.1038/s41467-021-24736-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — a A biotin-switch assay detected protein S-nitrosylation in HUVECs treated with Mannitol+nLDL or HG (25 mmol/L) and oxLDL (50 μg/mL). One independent experiment was performed. b S-nitrosylation of GNAI2 is significantly higher in coronary arteries of diabetic patients with CAD. The level of SNO-GNAI2 was quantified with total-GNAI2 and normalized to Control patients. n = 5 distinct samples for each group. c S-nitrosylation of GNAI2 is increased in the aortas of LDLr^−/− mice treated with STZ and HFD. The level of SNO-GNAI2 was quantified with total-GNAI2 and normalized to Vehicle + NC mice. n = 6 distinct samples for each group. d S-nitrosylation of GNAI2 is markedly increased in HUVECs treated with HG and oxLDL for 24 h. The level of SNO-GNAI2 was quantified with total-GNAI2 and normalized to Mannitol+nLDL-treated cells. n = 3 distinct samples for each group. N.D represents no detected. e S-nitrosylation of GNAI2 is significantly increased in HAECs treated with HG and oxLDL for 24 h. The level of SNO-GNAI2 was quantified with total-GNAI2 and normalized to Mannitol+nLDL-treated HAECs. n = 3 distinct samples for each group. N.D represents no detected. Data are represented as the Mean ± SEM. Unpaired two-tailed Student’s t-test was used for statistical analysis. Source data are provided as a Source Data file.