Table 1.
Clinicodemographic data of study population, stratified by OCB.
| Variables | OCB Negative |
OCB Positive |
P-value |
|---|---|---|---|
| N | 828 | 6494 | |
| Age at onset (mean (SD)) | 35.30 (10.77) | 33.45 (10.67) | < 0.001 |
| Age at CSF examination (mean (SD)) | 40.79 (11.99) | 38.13 (11.72) | < 0.001 |
| Male (%) | 267 (32.6) | 1894 (29.2) | 0.049 |
| Age at the start of platform IMT (mean (SD)) | 40.14 (10.47) | 37.61 (10.76) | < 0.001 |
| Age at the start of more potent IMT (mean (SD)) | 42.36 (11.07) | 39.24 (10.92) | < 0.001 |
| Phenotype (%) | |||
| PP | 78 (10.5) | 501 (7.9) | |
| RR | 460 (61.8) | 4077 (64.1) | |
| SP | 206 (27.7) | 1787 (28.1) | |
| Reached EDSS 3.0 (%) | 218 (40.0) | 2005 (44.4) | 0.055 |
| Reached EDSS 4.0 (%) | 177 (27.7) | 1511 (29.2) | 0.466 |
| Reached EDSS 6.0 (%) | 156 (21.7) | 1134 (19.9) | 0.297 |
| Converted to SP (%) | 171 (20.7) | 1494 (23.0) | 0.139 |
SD standard deviation, CSF cerebrospinal fluid, IMT disease modifying treatment, PP primary progressive, RR relapsing remitting, SP secondary progressive, EDSS expanded disability status scale.