Table 2.
Higher frequencies of peripheral polymorphonuclear myeloid-derived suppressor cells and regulatory T cells are detected in children with B-acute lymphoblastic leukemia.
| Cells | Patients (n = 31) | Control (n = 27) | p-value |
|---|---|---|---|
| Total MDSCs (%) | 4 ± 0.4 | 1.3 ± 0.1 | < 0.0001 |
| PMN-MDSCs (%) | 91.3 ± 1 | 87.5 ± 1 | 0.01 |
| MO-MDSCs (%) | 9.4 ± 0.8 | 11.2 ± 0.8 | 0.1 |
| CD4+(%) | 28.9 ± 1 | 40.6 ± 1 | < 0.0001 |
| CD4+CD25+low (%) | 17.8 ± 0.5 | 21.4 ± 0.5 | < 0.0001 |
| CD4+CD25+high (%) | 7.2 ± 0.5 | 4.9 ± 0.2 | < 0.0001 |
| CD4+CD25+highFoxP3+ (Tregs)(%) | 2.3 ± 0.1 | 1.9 ± 0.1 | < 0.0001 |
n number, MDSCs myeloid-derived suppressor cells, PMN-MDSCs Polymorphonuclear myeloid-derived suppressor cells, MO-MDSCs monocytic myeloid-derived suppressor cells, Tregs regulatory T cells. Results expressed as mean ± SE. Student's t-test; Significant p-value < 0.05.