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. 2021 Jul 22;11:14961. doi: 10.1038/s41598-021-94095-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Efficacy of camostat mesylate against hCOV-NL63-inoculated PREDICT96-ALI airway tissue. RT-qPCR analyses for viral copies in the apical wash of PREDICT96-ALI airway tissue at 0, 48 and 96 h p.i. with HCoV-NL63 across multiple MOIs. Solid lines show viral copies for MOI 0 (red, mock control), MOI 0.005 (blue) and MOI 0.05 (green) when treated with vehicle (DMSO), and dashed lines show corresponding viral copies when treated with 20 µM camostat mesylate. N = 2–4 tissue replicates per donor, time-point and condition. Replicates that did not meet the minimum signal intensity after 45 PCR cycles are displayed along the x-axis.