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. 2021 Jul 22;11:14990. doi: 10.1038/s41598-021-94467-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Kaplan–Meier analyses of renal outcome between the group A and B, stratified by baseline BP levels in patients with eGFR < 60 ml/min/1.73 m² (A,B) and ≥ 60 ml/min/1.73 m² (C,D). The difference in the effect on renal outcome between the group A and B was compared in the patients with eGFR < 60 ml/min/1.73 m² (A,B). Patients in group A (standard intervention) were simply instructed to follow the medical guidelines of the Japanese Society of Nephrology. On the other hand, patients in group B (advanced intervention) received an educational session by a dietitian and a letter regarding ideal lifestyle for CKD and were notified 1 week prior to the consultation. (A) Baseline SBP < 130 mmHg and DBP < 80 mmHg; No significant difference was observed. (B) The group B significantly reduced renal outcome compared to the group A. No significant difference was observed in patients with eGFR ≥ 60 ml/min/1.73 m² (C,D). BP blood pressure, SBP systolic blood pressure, DBP diastolic blood pressure, eGFR estimated glomerular filtration rate.