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. 2021 Jul 22;11:14993. doi: 10.1038/s41598-021-94418-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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After 4 weeks of oral lavage with P. gingivalis and S. gordonii (10¹⁰–10¹¹ CFU/ml), endothelial-dependent and -independent relaxation responses of pre-constricted aortic rings were monitored in response to acetylcholine (Ach) or sodium nitroprusside (SNP), respectively and, presented as mean ± SE; A: concentration response curve to Acetylcholine (Ach); B: concentration response curve to sodium nitroprusside (SNP) (n = 8 in each group). *Different to the control; P < 0.05 (2-Way ANOVA).