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. 2021 Jul 22;12(8):728. doi: 10.1038/s41419-021-04011-0

Fig. 7. Afatinib effectively inhibits FaDu-CDH1i xenograft tumor growth in vivo.

Fig. 7

A The two established xenograft athymic nude mouse models that carried FaDu-Ctrli and FaDu-CDH1i tumors were treated with vehicle and afatinib (10 mg/kg) in each group. Nude mice were sacrificed after 20 days of treatment, and tumors were dissected and imaged. B Tumor growth was measured every other day. The black arrow indicates the initial time of treatment. C Immunohistochemistry staining for CDH1, SOX2, Ki67, LC3B, and cleaved caspase-3 was performed in serial paraffin sections from xenograft tumors. Scale bar, 100 µm. All data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001.