Table 1.

Summary of performance evaluation of all six AD-related traits.

Outcome	Outcome type	AUC	AUPR	F1	Precision	Recall
Beta-amyloid	Pathologic, IHC	0.850	0.539	0.492	0.423	0.589
Braak staging	Pathologic, Silver Stain	0.860	0.599	0.530	0.487	0.581
CERAD	Pathologic, Silver Stain	0.833	0.502	0.508	0.457	0.571
Cognitive trajectory	Clinical	0.831	0.591	0.516	0.451	0.604
Global pathology	Pathologic, Silver Stain	0.882	0.622	0.577	0.507	0.671
Neurofibrillary tangles	Pathologic, IHC	0.962	0.858	0.754	0.677	0.852

The performance evaluation is on independent testing set on 450K array. The result reported here is in imbalanced setting (positive to negative CpGs ratio 1:10), which is closer to the real imbalanced setting in the human genome.