Table 2.
Top ten CpG loci for six AD-relevant traits.
| Chr | Position (bp) | Beta-amyloid | Braak staging | CERAD | Cognitive decline | Global pathology | Neurofibrillary tangles | Genes within 50 kb of associated CpG |
|---|---|---|---|---|---|---|---|---|
| 7 | 27148225 | 5.605 | 5.037 | 3.799 | 4.495 | 4.612 | 7.424 | HOTAIRM1, HOXA-AS2, HOXA-AS3, HOXA1, HOXA2, HOXA3, HOXA4, HOXA5, HOXA6, HOXA7 |
| 5 | 172175606 | 4.679 | 4.662 | 5.009 | 4.658 | 6.248 | 3.720 | DUSP1 |
| 7 | 47367933 | 4.008 | 4.736 | 5.251 | 4.254 | 5.278 | 5.210 | TNS3 |
| 19 | 46270392 | 4.462 | 4.447 | 6.311 | 4.362 | 4.937 | 3.727 | FBXO46, SIX5, DMPK, DMWD, RSPH6A, SYMPK |
| 6 | 35286078 | 5.141 | 5.947 | 4.497 | 3.731 | 3.762 | 5.072 | ZNF76, DEF6, PPARD |
| 19 | 10736075 | 4.130 | 5.977 | 3.387 | 4.047 | 4.400 | 5.845 | AP1M2, SLC44A2, ILF3, ILF3-AS1 |
| 9 | 116225986 | 3.408 | 4.977 | 4.253 | 3.630 | 5.307 | 5.893 | C9orf43, RGS3 |
| 1 | 59280358 | 3.065 | 6.248 | 3.973 | 5.179 | 5.130 | 3.755 | LINC01135, JUN |
| 19 | 15563592 | 6.579 | 4.549 | 3.132 | 3.849 | 4.009 | 5.215 | MIR1470, AKAP8L, WIZ, RASAL3, PGLYRP2 |
| 7 | 151433271 | 3.577 | 4.432 | 4.265 | 4.739 | 4.743 | 4.814 | PRKAG2 |
For each AD-associated trait, this table provides a Log-Scale Rank Scores (LRS) where an LRS of 1 corresponds to 90% percentile, LRS = 2 corresponds to 99% percentile, and so forth. Genes within 50 kbp of the region are provided. Genes with prior evidence of being associated with AD given in bold.