Table 4.
Associations of QoL domains at baseline with early virologic failure (VF) on second-line antiretroviral therapy (unadjusted and adjusted)
| QoL Domain | QoL Score Categorya | N | Incomplete self-reported adherence at week 4 N (%) | Early VF N (%) | OR for early VF (95%CI) | Trend p-valueb | OR for early VF (95%CI) adjusted for self-reported adherence at week 4 | Trend p-valueb |
|---|---|---|---|---|---|---|---|---|
| General Health Perception (GHP) | High | 31 | 5 (16.1) | 2 (6.4) | Ref | 0.87 | Ref | 0.84 |
| Medium | 212 | 44 (20.7) | 18 (8.5) | 1.34 (0.30–12.5) | 1.28 (0.28–12.0) | |||
| Low | 257 | 54 (21.0) | 17 (6.6) | 1.03 (0.23–4.68) | 0.97 (0.21–9.16) | |||
| Physical Functioning (PF) | High | 344 | 61 (17.7) | 22 (6.4) | Ref | 0.19 | Ref | 0.22 |
| Medium | 114 | 37 (32.5) | 11 (9.6) | 1.56 (0.66–3.50) | 1.34 (0.56–3.06) | |||
| Low | 41 | 5 (12.2) | 4 (9.8) | 1.58 (0.38–5.02) | 1.70 (0.40–5.44) | |||
| Role Functioning (RF) | High | 327 | 48 (14.7) | 19 (5.8) | Ref | 0.47 | Ref | 0.91 |
| Medium | 27 | 5 (18.5) | 5 (18.5) | 3.66 (0.98–11.5) | 3.57 (0.94–11.3) | |||
| Low | 146 | 50 (34.2) | 13 (8.9) | 1.58 (0.70–3.49) | 1.29 (0.55–2.93) | |||
| Social Functioning (SF) | High | 326 | 49 (15.0) | 20 (6.1) | Ref | 0.45 | Ref | 0.52 |
| Medium | 125 | 47 (37.6) | 13 (10.4) | 1.77 (0.78–3.89) | 1.43 (0.61–3.24) | |||
| Low | 49 | 7 (14.3) | 4 (8.2) | 1.36 (0.32–4.32) | 1.37 (0.32–4.39) | |||
| Cognitive Functioning (CF) | High | 275 | 53 (19.3) | 20 (7.3) | Ref | 0.67 | Ref | 0.53 |
| Medium | 167 | 45 (26.9) | 13 (7.8) | 1.08 (0.50–2.35) | 0.99 (0.43–2.17) | |||
| Low | 58 | 5 (8.6) | 4 (6.9) | 0.94 (0.23–2.98) | 1.08 (0.25–3.45) | |||
| Pain (P) | High | 249 | 38 (15.3) | 16 (6.4) | Ref | 0.033 | Ref | 0.08 |
| Medium | 111 | 20 (18.0) | 4 (3.6) | 0.54 (0.13–1.74) | 0.53 (0.12–1.70) | |||
| Low | 140 | 45 (32.1) | 17 (12.1) | 2.01 (0.92–4.41) | 1.73 (0.77–3.86) | |||
| Mental Health (MH) | High | 124 | 10 (8.1) | 5 (4.0) | Ref | 0.12 | Ref | 0.11 |
| Medium | 263 | 74 (28.1) | 20 (7.6) | 1.96 (0.69–6.83) | 1.56 (0.53–5.60) | |||
| Low | 113 | 19 (16.8) | 12 (10.6) | 2.82 (0.89–10.6) | 2.56 (0.80–9.66) | |||
| Energy/Fatigue (E/F) | High | 129 | 10 (7.7) | 6 (4.6) | Ref | 0.29 | Ref | 0.28 |
| Medium | 234 | 73 (31.2) | 19 (8.1) | 1.81 (0.67–5.68) | 1.39 (0.49–4.53) | |||
| Low | 137 | 20 (14.6) | 12 (8.8) | 1.96 (0.66–6.58) | 1.82 (0.60–6.13) |
a
QoL score categories: high = 100; medium = 75-<100; low = <75;
b
p-values from logistic regression model including QoL score as a quantitative score