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. Author manuscript; available in PMC: 2021 Aug 11.
Published in final edited form as: J Allergy Clin Immunol. 2021 Jan 23;148(2):533–549. doi: 10.1016/j.jaci.2021.01.008

Figure 1. Concepts and models tested.

Figure 1.

(A) Conceptual framework of allergic asthma/allergic rhinoconjunctivitis (AA/ARC) pathogenesis; resistance or adaptation vs. maladaptation to inflammation induced by environmental triggers signifies preservation vs. degradation of inflammatory memory. (B) Feedback loop of epithelial integrity (Epiintegrity) and inflammation. (C) Model based on our findings (18) showing that the imbalance between Epiintegrity and airway allergic inflammation distinguished non-atopic, non-allergic controls (ctrl.) and persons with HDM-associated perennial ARC (HDM-PARC). (D) Association of airway Epiintegrity and inflammation status with mild, moderate (mod), and high HDM-PARC severity and evoked phenotypes. (E) Intercompartment crosstalk. (F) HDM study design. EC, epithelial cells; ILCs, innate lymphoid cells; NK, natural killer; slgE, HDM-specific IgE; Th2, T-helper 2.