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. Author manuscript; available in PMC: 2021 Aug 11.
Published in final edited form as: J Allergy Clin Immunol. 2021 Jan 23;148(2):533–549. doi: 10.1016/j.jaci.2021.01.008

Figure 5. Expression of AA risk correlates in whole blood transcriptomes of persons with HDM-PARC.

Figure 5.

Trajectories of (A) NK/asthmaAltman, NKactivated, NKresting, and CD8EM gene signature scores (z-scores), and (B) TLR7, IRF7, and STAT1 log2-transformed normalized gene expression (NGE), and interferon-stimulated genes (ISG) signature score (z-scores) in whole blood transcriptomes of HDM-PARC participants obtained at pre- and post-exposure (Exp) 1 and post-Exp 4 of ACC-I stratified by CD8hi and CD8lo, and HDM-PARC phenotypes (resilient [R], adaptive [A], maladaptive [M]). (top) schema representing genes involved in the human rhinovirus (HRV) pathway. P, for an overall difference between groups (CD8lo vs. CD8hi, M vs. R, or M vs. A). Hi, higher; Lo, lower. Methods for deriving significance values in Supplement.