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. Author manuscript; available in PMC: 2021 Aug 11.
Published in final edited form as: J Allergy Clin Immunol. 2021 Jan 23;148(2):533–549. doi: 10.1016/j.jaci.2021.01.008

Figure 8. Combinatorial model of HDM-PARC and translation of maladaptive traits to asthma severity.

Figure 8.

(A) Combinatorial model summary of nasal cell and peripheral blood traits and clinical features of the HDM-PARC phenotypes. Hi, higher. (B) Median (IQR) gene signature scores (z-scores) in sputum samples obtained from controls and patients with asthma that clustered into transcriptional endotypes of asthma (TEA) clusters 1, 2, and 3 (source: GSE56396; (67)). P, determined by Welch’s t-test comparing TEA cluster 1 vs. 3. (Right) Study group characteristics. ICS, inhaled corticosteroids. (C) Schema of expression levels of the epithelial integrity- and inflammation-related pathways in HDM-PARC phenotypes (resilient [R], adaptive [A], maladaptive [M]). (D) Gain- and loss-of-function traits (GOF and LOF, respectively) that influence HDM-PARC and possibly asthma severity. (E) Summary schema representing number of GOF and LOF pathogenic hits impacting HDM-PARC phenotypes. Methods for deriving significance values in Supplement.