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. 2021 Jul 22;11:14948. doi: 10.1038/s41598-021-94212-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CBD, CBDA, CBDVA, CBG and Δ⁹-THC are substrates of BCRP. Concentration–time curves for (a) CBDA, (b) CBD, (c) CBDVA, (d) CBG and (e) Δ⁹-THC in wildtype (left panel) and BCRP-expressing (middle panel) MDCK cells in the basolateral to apical (B > A) and apical to basolateral (A > B) directions. Right panels represent concentration–time curves for cannabinoids in cells expressing BCRP in the presence of the inhibitor elacridar (dashed lines). Data are expressed as means ± SEM, with n = 4 per time point. Curves represent fits to a linear regression and transport efflux ratios (r) are listed (*p < 0.05, **p < 0.005, ***p < 0.0005 compared to wildtype; Extra sum-of-squares F test).